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Name: Bobby

Question:
I have been on bioidental hormones for 3 years. At first things were great but for the past year I have started bleeding on a regular basis. I take progesterone cream--200 mg once a day. I get a pellet twice a year. My doctor has adjusted my levels, I get regular blood tests and ultrasounds to make sure nothing is going wrong with my lining but I am still bleeding--usually a couple days of the week for the whole month. I am wondering if I should try taking prometrium instead. Are there any issues with the liver when taking prometrium? I am 53 years old and had stopped having periods when I went on bioidenticals. My doctor keeps adjusting my levels but we just can't seem to find that sweet spot.
Thank You,
bobby

Answer:
Bobby,
The blood spotting you are describing is one of the most common side effects of pellets. Your pellet delivers a fairly steady amount of estradiol over time. The progesterone cream applied once a day is a jolt of progesterone, once daily. These fluctuations in hormone balance could be the culprit! The prometrium may have a similar effect. I would recommend a more "gradual" release progesterone tablet. I compound a 200mg tablet designed to release over 8-10 hours. Our progesterone tablets (BLA system) works great with pellets. They are designed for lymphatic absorption (avoids liver). There is more information on our website. I think this is a great option for you.
Terri

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